To reduce this health burden, a comprehensive prevention and control. Liver fluke infection with opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis remains a major public health problem in many parts of asia and eastern europe. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Because of its relatively low conservation, the pm gene may be a convenient genetic marker for studying phylogenetic. Moreover, specific amplification was also achieved by the use of fecal. Pdf investigation on opisthorchis felineus occurrence and. A significant difference as compared with the control group p values 05. The liver fluke infection in thailand was caused by o. Endemicity of for species identification of opisthorchis o. Parasite liver and biliary tree parasites 69 cdc dpdx opisthorchiasis liver and biliary tree parasites 69 liver and biliary tree parasites 69. The cat liver fluke, also known as opisthorchis felineus, is a trematode parasite that lives in water. Opisthorchis felineus infection provokes timedependent accumulation of.
Opisthorchiasis caused by foodborne trematode opisthorchis felineus is a substantial public health problem, with 17 million persons infected worldwide. Investigation on opisthorchis felineus occurrence and life cycle in italy article pdf available in veterinary parasitology 17712. Opisthorchiasis is widespread in russia, especially western siberia. The cdna sequence of opisthorchis felineus paramyosin pm was determined and shown to have 6670% homology with two schistosomes and two cestodes.
Chromosomal disarrangement and immunoreactivity of golden hamsters infected with opisthorchis felineus. Opisthorchiasis genetic and rare diseases information. Opisthorchis felineus infection provokes timedependent. We report 2 outbreaks of opisthorchis felineus infection caused by the consumption of tench filets tinca tinca from a lake in italy. Characteristics of liver fibrosis associated with chronic. Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. Human illnesses caused by opisthorchis felineus flukes, italy. Opisthorchis felineus 20200510 20200510 tagged medical chemical corporation. The infection is associated with a number of hepatobiliary diseases, including cholangitis, obstructive jaundice, hepatomegaly, cholecystitis, cholelithiasis and cholangiocarcinoma.
Opisthorchis felineus rivolta, 1884 is a member of the triad of epidemiologically important fishborne liver trematodes, which also includes o. Experimental and modelling investigations of opisthorchis. An integrated epidemiological study of opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs dogs and cats and intermediate hosts cyprinid fish was carried out in the vicinity of huay luang dam, udon thani province, in the north east of thailand. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o. Opisthorchis felineus is a trematode that is transmitted to humans through the consumption of raw freshwater fish of the family cyprinidae. Medical care and loss of wages caused by opisthorchis viverrini in laos and. Opisthorchis felineus life cycle home opisthorchis felineus life cycle 20200511 20200511 tagged life cycle of opisthorchis viverrini. It demonstrates high diagnostic and therapeutic potential. For language access assistance, contact the ncats public information officer. Epidemiology of opisthorchis viverrini in an endemic area.
When present, symptoms fever, nausea, abdominal pain, and myalgias were mild. Opisthorchis viverrini poirier 1886 poirier 1886 encyclopedia. Chromosomal disarrangement and immunoreactivity of golden. The tumorigenic liver fluke opisthorchis viverrini. In 1891, russian parasitologist, konstantin nikolaevich vinogradov 18471906 found it in a human, and named the parasite a siberian liver fluke. Opisthorchis felineus cat liver fluke is commonly found in eastern europe and russia. Hemozoin from the liver fluke, opisthorchis felineus. Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family opisthorchiidae. There is a general, inverse relationship between helminth infection and allergic diseases including bronchial asthma ba. Opisthorchiasis is generally known as cat liver fluke disease, if it is caused by o. Clinical signs are variable, and infestation with a moderate number of. Domestic animals, especially cats, become infected by eating insufficiently cooked fish. A study of tribendimidine effects in vitro and in vivo on the liver fluke. The international agency for research on cancer classifies the infection with the liver flukes opisthorchis viverrini and.
Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. The foodborne liver fluke opisthorchis felineus is an epidemiologically important species and the causative agent of opisthorchiasis across an. Phylogenetic analysis revealed an almost equal distance between o. Opisthorchis felineus wikipedia, a enciclopedia livre. Molecular identification of clonorchis sinensis and.
The eggs of opisthorchis are very similar to those of clonorchis, another liver fluke, but can be distinguished by microscopic features. It hitches a ride with an intermediate host, typically the land snail, which is then ingested by another intermediate host, such as the lizard and frog. Human illnesses caused by opisthorchis felineus flukes. Proteins and other mediators released from parasitic worms exert cogent downmodulation of atopic and other allergic reactivity. The tumorigenic liver fluke opisthorchis viverrini multiple. It is also present in puerto rico and possibly other caribbean islands.
Fish sharing as a risk factor for opisthorchis viverrini. Comparison of infectivity, metacercarial burden and host. Opisthorchis infection does not result from drinking river water or other nonpotable water. All structured data from the file and property namespaces is available under the creative. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. If you have problems viewing pdf files, download the latest version of adobe reader.
Histological analysis of the liver of uninfected hamster control. First report and molecular identification of opisthorchis. Infections with the opisthorchid liver flukes clonorchis sinensis, opisthorchis viverrini, and o. The life cycle and parasitic system of opisthorchis felineus in the. Opisthorchis felineus small biliary fluke, causing opisthorchiasis. Complete sequencing of the mitochondrial genome of. Worldwide, the number of cases of human infection has been estimated to be 1. In 1927, prommas identified the worms found at an autopsy of a 17yearold thai male residing in roiet, northeast thailand, as o. The term fluke means flatfish, since these parasites are flat. We investigated the immune activities of an immortalized murine dendritic cell mdc line jawsii and of primary human dendritic. It was first discovered in 1884 in a cats liver by sebastiano rivolta of italy.
In this work the formation of cocalled hemozoin knobs the bile duct ectasia filled up by hemozoin pigment in opisthorhis felineus infected hamster liver has been observed. Similar to bile duct cancer or cholangiocarcinoma cca in the western world, opisthorchiasisassociated cca in southeast asia is an aggressive cancer with high mortality rates. Infeetion with livr flukes opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1. Opisthorchis felineus an overview sciencedirect topics. Opisthorchis felineus life cycle pixelmasterdesign. Liver fluke infection is recognized as the major risk factor of cholangiocarcinoma. Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. Opisthorchis viverrini and clonorchis sinensis are liver flukes a type of flatworm that. Pdf opisthorchis viverrini and opisthorchis felineus. Pdf the liver fluke opisthorchis felineus is a member of the triad of. They need to be ingested by freshwater gastropod snail, the first intermediate host, to develop into sporocysts, rediae, and freeswimming cercariae, the stage infective for the second intermediate host, cyprinoid fish 3, 7.
The causative agent, the siberian liver fluke opisthorchis felineus, infests the liver, gallbladder, and pancreas of man, cats, and dogs. Early identification of the infection is essential to provide timely and appropriate chemotherapy to patients. By the end of the 19th century, distoma contained so many species that blanchard introduced the genus opisthorchis for elongated flat flukes with testes in the posterior end of the body. Opisthorchis felineus, a hepatic trematode, is the causative agent of opisthorchiasis, a dangerous disease in both human beings and animals. Together they affect more than 45 million people and 600750 million people are at risk in the endemic regions of eurasia. Hemozoin knobs in opisthorchis felineus infected liver. Opisthorchis felineus has a complex life cycle involving three hosts. Pdf opisthorchis viverrini and opisthorchis felineus researchgate. Plasma metabolomics of the time resolved response to. The liver fluke opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of eurasia.
Sep 17, 2015 hemozoin is the pigment produced by some bloodfeeding parasites. Infection with opisthorchis felineus induces intraepithelial. Since then, cases of opisthorchiasis were reported each year. After ingestion by a suitable snail first intermediate host, the eggs release miracidia, which undergo in the snail several developmental stages sporocysts, rediae. Opisthorchis viverrini and opisthorchis felineus, also called the southeast asian liver fluke and. Hemozoin is the pigment produced by some bloodfeeding parasites.
The mlpa products could be successfully detected using a capillary sequencer figure 5. Opisthorchis felineus article about opisthorchis felineus. Epidemiology of opisthorchis viverrini in an endemic area of. The acta2 gene data are normalized to gene hprt1, the tgf. The eggs are shed in the biliary tree of fisheating mammals and are passed with feces. These liver flukes are known to cause serious human diseases affecting bile ducts and the gall bladder.
Macrophotograph of the liver of uninfected hamster control at a 5, b 24 and c 48 weeks after the start of the experiment. Infection of the definitive host follows the consumption of fish contaminated with metacercariae. It hitches a ride with an intermediate host, typically the land snail, which is then ingested by another intermediate host, such as. Fish intermediate hosts of the liver flukes a opisthorchis viverrini. More than one stool sample may be needed to detect the eggs.
They have a knob at the abopercular end that may be prominent, inconspicuous, or absent. Additionally, cysts containing the parasite can sometimes be detected by ultrasound, ct, or. The main sources of the disease are infected persons and animals, whose feces carry the parasites eggs to water. The purpose of the present study was to determine the complete mitochondrial dna sequence of this flatworm. We investigated the immune activities of an immortalized murine dendritic cell mdc line jawsii and of primary human dendritic cells. A high prevalence has been reported in byelorussia, russia, and the ukraine. Parasite liver and biliary tree parasites 69 cdc dpdx opisthorchiasis. Expression of key genes of fibrogenesis in syrian hamsters during chronic opisthorchiasis. Sep 02, 2011 we use your linkedin profile and activity data to personalize ads and to show you more relevant ads. May first report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar win pa pa aung 0 1 2 thi thi htoon 0 2 htay htay tin 0 2 kyi kyi thinn 0 2 oranuch sanpool 0 1 2 jurairat jongthawin 0 1 2 lakkhana sadaow 0 1 2 issarapong phosuk 0 1 2 rutchanee rodpai 0 1 2 pewpan m. Examination of faeces and duodenal secretion discovered eggs of opisthorchis felineus, a liver fluke especially common. Lightly salted, smoked, or pickled fish can contain infectious parasites. It is known to cause a significant health burden in the opisthorchiasis region in thailand and possibly throughout mainland southeast.
Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus. Opisthorchis infection can be prevented by avoiding raw or undercooked freshwater fish. The purpose of the present study was to determine the. Opisthorchis felineus and metorchis bilis metacercariae in. Media in category opisthorchis the following 2 files are in this category, out of 2 total. In the 1930s, helminthologist hans vogel of hamburg published an. He chose rivoltas opisthorchis felineus as the type species. The human liver fluke, opisthorchis viverrini sensu lato s. Opisthorchis felineus, or cat liver fluke is a trematode parasite that infects the liver in mammals. Opisthorchiasis is prevalent in western siberia and in the region of the dnieper. Feline liver fluke worm is a killer feline instincts. Opisthorchiasis caused by opisthorchis viverrini o. Diagnosis of opisthorchis infection is based on microscopic identification of eggs in stool specimens. This chronic disease is associated with hepatobiliary inflammation, cholangiocyte dysplasia, cholangiofibrosis, intraepithelial neoplasia, and even cholangiocarcinoma among chronically infected individuals.
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